Policier intègre, Serpico lutte contre la corruption généralisée au sein de la police new-yorkaise. Détesté de tous, collègues comme supérieurs, il ne pourra compter que sur lui-même pour mener à bien sa croisade pour la justice.

Isaac Geldhart is a Holocaust survivor who, overcome by grief at the recent death of his wife, seems determined to run his publishing firm into the ground by printing books that have no hope of financial success. His son Aaron, who also works at the company, grows frustrated with Isaac's emotional decline and attempts to take over the firm. The resulting crisis involves Isaac's other two children, his daughter Sarah and his dying son Martin.